There has been a lot of talk lately about Echinacea, the popular immune herb, since a recent study came out showing no effectiveness.
The researchers tried to design the study well, but there were a few flaws.
First, the dose was much lower than is normally used for cold relief. Most who take Echinacea effectively take three to six times the dose subjects were given in the study. This study used 1.5 ml three times per day of a 1:5 tincture. 1:5 is about as weak as tinctures get, meaning there was one part plant to five parts liquid.
Second, the preparation is questionable at best. The researchers used three types of extraction, one of which tends to have good results but may not get all active constituents out, and the other two were relatively low alcohol. Herbalists use alcohol as close to 100% as possible to extract plant constituents, not the 20% and 60% they used. This should not be confused with the percentages you often see on tincture bottles, which represents the percentage alcohol in the product used to preserve.
Third, the species used, Echinacea angustifolia, is one which has poorer results in trials. Echinacea purpurea has shown much stronger results. In fact, in some studies, Echinacea angustifolia has been shown to DECREASE immune function and it is used in some autoimmune diseases like lupus, MS, and alopecia areata for this purpose.
Fourth, the infections were artificially induced using one type of virus in young healthy people in a closed situation. This does not mimic real life. Drs. Turner and Gangemi, authors in this study, also found negative results with artificially induced colds in a previous study. Turner RB, Riker DK, Gangemi JD. Ineffectiveness of Echinacea for prevention of experimental rhinovirus colds. Antimicrob Agents Chemother 2000;44(6):1708-9
Fifth, the researchers studied the preventive effects of Echinacea (taking it before a cold), which is fine, but it has already been shown that Echinacea is not very effective at preventing colds. It seems to be much more effective when taken during a cold to reduce symptoms and duration.
This study is not conclusive. Echinacea has been formally researched in hundreds of studies and has shown positive effects. It increases the number and function of white blood cells (immune cells). It acts to kill viruses and bacteria. It contains inulin, which activates the immune system. It preserves connective tissue. Echinacea has been shown to reduce the symptoms and duration of the common cold.
It is important to remember that plants are not pharmaceuticals. A tiny dose of a plant extract usually has little effect on the body.
It is also important to remember that there are many many immune enhancing herbs. If you don’t take Echinacea, you have at least ten commonly available alternative choices. We always use more than one approach when fighting colds!
You can prevent colds and flu!
The recent study showing no effectiveness:
N Engl J Med. 2005 Jul 28;353(4):341-8
Some other studies and books:
Pizzorno, J., et al: The Textbook of Natural Medicine, 2nd ed., Churchill Livingstone, New York, NY. 1999
Lininger et al: Healthnotes: Clinical Essentials, Herb Monographs. Prima Publishing, Rocklin, CA. 2001
Mills, S. and Bone, K. Principles and Practice of Phytotherapy . Churchhill Livingstone, New York, NY. 2000
PDR for Herbal Medicines. Medical Economics Company Inc., Montvale, NJ. 2001
Hu, C. Studies on the antioxidant activity of Echinacea root extract. J Agric Food Chem. 2000 May;48(5):1466-72.
Blumenthal, M., The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines, First Edition, American Botanical Council. 1998
Kim LS, Waters RF, Burkholder PM. Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial. Altern Med Rev 2002;7(2):138-49.
Melchart D, Linde K, Worku F, et al. Results of five randomized studies on the immunomodulatory activity of preparations of Echinacea. J Altern Complement Med 1995;1(2):145-60.
Melchart D, Clemm C, Weber B, et al. Polysaccharides isolated from Echinacea purpurea herba cell cultures to counteract effects of chemotherapy – a pilot study. Phytother Res 2002;16(2):138-42.
Schulten B, Bulitta M, Ballering-Bruhl B, et al. Efficacy of Echinacea purpurea in patients with a common cold. A placebo-controlled, randomized, double-blind clinical trial. Arzneimittelfor schung 2001;51(7):563-8.
Brinkeborn RM, Shah DV, Degenring FH. Echinaforce and other Echinacea fresh plant preparations in the treatment of the common cold. A randomized, placebo-controlled, double-blind clinical trial. Phytomedicine 1999;6(1):1-6.
Lindenmuth GF, Lindenmuth EB. The efficacy of Echinacea compound herbal tea preparation on the severity and duration of upper respiratory and flu symptoms: a randomized, double-blind placebo-controlled study. J Altern Complement Med 2000;6(4):327-34.